KMID : 0389520110180010035
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Sleep Medicine.Psychophysiology 2011 Volume.18 No. 1 p.35 ~ p.39
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Association Study between Per3 Gene Polymorphism and Diurnal Preference
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Kang Seung-Gul
Choi Tae-Young Yoon Ho-Kyoung Park Young-Min Kim Leen Lee Heon-Jeong
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Abstract
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Objective: Diurnal preference is an attribute reflecting whether people are alert and preferring to be active either early or late in the day. It also referred to as chronotype or morningness-eveningness trait. The PER3 genes have been known to influence diurnal preference. In this study, we have investigated the associations between the PER3 gene polymorphisms and diurnal preference in a healthy young population, controlling for the social and environmental confounding factors.
Methods: The participants in this experiment included 299 unrelated medical college students (M=191, F=108), with a mean age of 22.9 years. Diurnal preference was measured by a single administration of the 13-item Composite Scale for Morningness (CSM). Genotyping of the PER3 VNTR (rs57875989) was performed using polymerase chain reaction. A two-tailed alpha of 0.05 was chosen.
Results: The meanSD score on the CSM scale for all subjects was 31.906.39. There was no significant difference in total CSM score between gender groups, although females showed a trend towards higher morningness score. Although PER3 5R/5R showed the tendency towards high CSM scores, there were no significant differences on CSM scores among genotypes and allele status of PER3 VNTR (rs57875989).
Conclusions: We could not confirm that the PER3 VNTR is associated with diurnal preference in a Korean healthy young population. The future studies need to investigate the association between diurnal preference and other polymorphisms of PER3 gene in larger sample of Korean young healthy population.
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KEYWORD
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Diurnal preference, Polymorphism, PER3, Morningness
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